WASHINGTON — Republican finger-pointing commenced Friday after the Senate's dark-of-night defeat of the GOP effort to repeal much of the Obama health care law, a startling blow to President Donald Trump and congressional leaders.

"They should have approved health care last night," Trump said in Brentwood, N.Y., where he delivered remarks on gang violence. "But you can't have everything."

The "skinny repeal" bill — erasing parts of President Barack Obama's law — was rejected just before 2 a.m. EST on a vote of 51-49. Though Trump seemed to shrug it off and added that "we're going to get it done," the rejection is one of the worst legislative losses of his presidency.

Earlier Friday, he tweeted, "3 Republicans and 48 Democrats let the American people down," after GOP leaders failed to patch party divisions and win passage for the last-ditch bill.

All Democrats were joined by GOP Sens. Susan Collins of Maine, Lisa Murkowski of Alaska and the ailing John McCain. The 80-year-old Arizona senator made a dramatic return to the Capitol Tuesday after being diagnosed with brain cancer, when he cast a decisive procedural vote that for a time advanced the legislation.

Following rejection of two broader GOP repeal plans earlier in the week, Friday's vote cast doubt on whether divided Senate Republicans can advance any health bill despite seven years of promises to repeal "Obamacare."

In a statement, McCain called the Senate's inability to craft wide-ranging legislation "inexcusable." He said lawmakers should write a bill with "input from all of our members, Republicans and Democrats" and "stop the political gamesmanship."

House leaders had no hesitation about blaming the Senate for the collapse of one of the GOP's paramount priorities. In a statement, Speaker Paul Ryan, R-Wis., pointedly said "the House delivered a bill" and said he was "disappointed and frustrated." Nearly three months earlier, the House approved its health care package after several embarrassing setbacks.

He added, "But we should not give up. I encourage the Senate to continue working toward a real solution that keeps our promise."

Underscoring the House's view of where the fault lie, leaders opened a morning meeting of the chamber's GOP lawmakers by playing audio of Gordon Lightfoot's "The Wreck of the Edmund Fitzgerald," which recounts the 1975 wreck of a freighter in Lake Superior. Several lawmakers said House deputy whip Patrick McHenry, R-N.C., told them the song was meant as a reference to the Senate.

One moderate Republican said Trump shared responsibility for the bill's breakdown. "One of the failures was the president never laid out a plan or his core principles and never sold them to the American people," said Rep. Charlie Dent, R-Pa. "Outsourced the whole issue to Congress."

The measure defeated Friday would have repealed an Obama mandate that most people get health insurance and would have suspended a requirement that larger companies offer coverage to their employees. It would have also suspended a tax on medical devices and denied federal payments to Planned Parenthood for a year.

"This is clearly a disappointing moment," Senate Majority Leader Mitch McConnell, R-Ky, said. "I regret that our efforts were not enough this time."

"It's time to move on," he said. McConnell put the health bill on hold and announced that the Senate would move onto other legislation next week.

Conservative Rep. Mo Brooks, R-Ala., who's running for a vacant Senate seat, suggested it was time for McConnell to relinquish his post.

"If they're going to quit, well then by golly, maybe they ought to start at the top with Mitch McConnell leaving his position and letting somebody new, somebody bold, somebody conservative take the reins," Brooks said on CNN. He added, "How is he going to get the job done on the rest of President Trump's agenda?"

The amendment was a last resort for Senate Republicans to pass something — anything — to trigger negotiations with the House.

"I hope this is a turning point," Senate Minority Leader Charles Schumer of New York, said Friday.

Health and Human Services Secretary Tom Price said in a statement that the Trump administration would pursue its health care goals through regulation. "This effort will continue," Price said. But insurers, hospitals, doctors, and consumer groups are pressing the administration to guarantee billions of dollars in disputed subsidies to help stabilize insurance markets around the country.

McConnell had introduced a pared-down health care bill late Thursday that he hoped would keep alive Republican ambitions to repeal "Obamacare."

Ryan had seemingly opened a path for McConnell by signaling a willingness to negotiate a more comprehensive bill with the Senate. Some Republican senators had been concerned that the House would simply pass McConnell's "skinny bill" and send it to Trump. That would have sent a shock wave through health insurance markets, spiking premiums.

Ryan sent senators a statement saying that if "moving forward" requires talks with the Senate, the House would be "willing" to do so. While Sen. Lindsey Graham, R-S.C., eventually said he was reassured by Ryan's words, McCain remained unconvinced.

"Not sufficient," McCain said.

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Associated Press writers Ricardo Alonso-Zaldivar, Stephen Ohlemacher and Kevin Freking contributed to this report.

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