Notre Dame's reward for earning a No. 1 seed was a trip to Iowa City and a date with Tennessee-Martin, which hardly resembled a No. 16 seed.
The Fighting Irish can go anywhere and beat anyone if they dominate the paint the way they did against the undersized Skyhawks.
Jewell Loyd scored 27 points and Notre Dame blew past Tennessee-Martin 97-64 on Sunday.
Kayla McBride had 22 points and 10 rebounds for the Fighting Irish (32-1), who outrebounded UT-Martin 49-14 and enjoyed a 55-22 advantage in points in the paint.
"I thought offensively we really went after it," Notre Dame coach Muffet McGraw said. "We're capable of getting to the backboards and boxing out. We did a really good job defensively."
Heather Butler scored 23 of her season-high 37 points in the first half to keep UT-Martin (19-15) in the game. But Notre Dame closed the first half on an 11-0 run and jumped ahead 60-33 with 17 minutes left.
Notre Dame star Skylar Diggins finished with just 10 points and six assists. But the Fighting Irish didn't need a big game from the guard in their 27th straight win heading into Tuesday's second-round matchup with Iowa or Miami.
Purdue 77, Liberty 43: Sam Ostarello heard all the talk for the past week about how the Liberty Lady Flames rebound better than anyone in the country. Then the Purdue senior went out and showed she's pretty good at hitting the boards herself.
Ostarello scored 10 points and grabbed 17 rebounds as fourth-seeded Purdue routed Liberty.
The Boilermakers (25-8) improved to 19-1 in the first round with their 16th straight victory to open the tournament.
No. 13-seeded Liberty (27-7) hadn't played a Big Ten team since 2005 when the Lady Flames beat Penn State for their first NCAA tournament win. Liberty had the nation's best rebounding margin with a 17.5 edge per game, but couldn't beat Purdue on the boards in ending a 14-game winning streak.
Courtney Moses scored 21 points, going 5 of 8 from 3-point range for Purdue. KK Houser added 15 points. Ostarello came in leading the Big Ten with 9.9 rebounds per game and set the tone as Purdue had a 40-38 edge on the boards.
No. 5 Louisville 74, Middle Tennessee 49: Shoni Schimmel scored 20 points, and fifth-seeded Louisville beat Middle Tennessee for its fifth straight opening NCAA tournament win under coach Jeff Walz.
Louisville (25-8) will play No. 4 seed Purdue, a 77-43 winner over Liberty, on Tuesday night in the second round of the Oklahoma City Regional.
Middle Tennessee (25-8) had won seven in a row. The Blue Raiders have dropped five straight first-round NCAA games.
Florida State 60, Princeton 44: Leonor Rodriguez and Morgan Toles each scored 12 points and Florida State beat Princeton.
The Seminoles won their 10th straight first-round game and denied the Tigers their first NCAA tournament victory.
No. 2 Kentucky 61, No. 15 Navy 41
DeNesha Stallworth scored 18 points and Jennifer O'Neill added nine of her 12 points in the second half to lead Kentucky over Navy.
The Wildcats (28-5) trailed by one at the half before O'Neill, who grew up in New York, took over. She hit a quick 3-pointer to start a 12-2 run. The sophomore guard had seven points, a steal and an assist during the burst
No. 3 North Carolina 59, No. 14 Albany 54: Tierra Ruffin-Pratt scored a career-high 30 points, and North Carolina squeezed past Albany to stagger into the second round of the NCAA tournament.
North Carolina trailed 28-23 at halftime and 48-44 with just under 10 minutes left before rallying behind Ruffin-Pratt, who scored 17 of the Tar Heels' final 21 points — including two clinching free throws with 10.8 seconds left.
No. 6 Delaware 66, No. 11 West Virginia 53: Elena Delle Donne scored 33 points and led a second-half surge that carried Delaware past West Virginia.
Playing on their home floor before a sellout crowd, the Blue Hens trailed 33-26 at halftime before bouncing back to extend their school-record winning streak to 26 games.
No. 7 Dayton 96, No. 10 St. John's 90, 2 OT: Andrea Hoover scored a career-high 24 points and Dayton outlasted St. John's.
It was the first double overtime game in the tournament since 2000 when Vanderbilt beat Kansas.
No. 2 Duke 67, No. 15 Hampton 51: Tricia Liston scored 13 of her 20 points in the second half and Duke pulled away to beat Hampton.
Elizabeth Williams added 18 points and Haley Peters finished with 12 points and 10 rebounds for the Blue Devils (31-2).
They watched Hampton trim their 19-point lead to six before recovering with a 23-8 run that gave them their 20th straight NCAA tournament-opening victory.
No. 7 Oklahoma State 73, No. 10 DePaul 56: Toni Young scored 20 of her 25 points in the first half to help Oklahoma State beat DePaul.
Liz Donohoe added 14 points for the seventh-seeded Cowgirls (22-10), who blew nearly all of a 16-point lead before taking back control with a 13-0 run. Young also grabbed 13 rebounds.
Anna Martin scored 12 points for the 10th-seeded Blue Demons (21-12).
Stanford 72, Tulsa 56: Chiney Ogwumike had 29 points, eight rebounds and three assists, and top-seeded Stanford pulled away in the second half from the 16th seed.
Amber Orrange added 14 points, six rebounds and three assists for the Cardinal (32-2), who needed more than a half to get rolling while playing at home in Maples Pavilion coming off final exams and a two-week layoff since winning the Pac-12 tournament.
Penn St. 85, Cal Poly 65: Maggie Lucas scored 19 points, Alex Bentley added 18 and third-seeded Penn State overwhelmed NCAA women's tournament newcomer Cal Poly.
While the dynamic Lucas scored from all over the court, Penn State (26-5) also used its size advantage to assert itself inside on both ends.