Bria Hartley scored 21 points and Breanna Stewart added 20 to lead UConn to its 30th straight win, a 102-41 rout of visiting SMU on Tuesday night.
Kaleena Mosqueda-Lewis scored 16 points, grabbed 11 rebounds and dished out seven assists as all five starters reached double figures for UConn (24-0, 10-0 American Athletic Conference).
Stefanie Dolson had 16 points, 11 rebounds and five of UConn's 14 blocked shots. Moriah Jefferson had 14 points and five assists.
Keena Mays, the conference's top scorer had 20 points to lead SMU (14-8, 5-6), which lost for the first time in four games. But she hit just three of her 12 shots in the first half, when UConn put the game away.
UConn opened the game with 19-0 run and led by 37 at halftime.
SMU missed its first 11 shots and was held without a point for more than 5 minutes before Kamy Cole hit a pair of free throws.
A Dolson layup put the Huskies up by 30 at 47-17, and a 3-pointer by Mosqueda-Lewis just before halftime gave the Huskies a 54-17 lead.
The Huskies opened up the second half with a 3-pointer from Mosqueda-Lewis and pushed the lead past 40 points when she hit a jumper with more than 16 minutes left in the game.
The lead was 84-32 after a 3-pointer by Hartley and a layup by Jefferson pushed it over 60 points with more than 5 minutes left.
UConn held SMU to 20 percent shooting. The Mustangs hit just 14 of their 70 shots.
UConn, which came in averaging more than 8 blocks a game, were just three shy of the school's single-game record, led by Dolson and Stewart, who had four.
UConn had 31 assists on its 40 baskets. Jefferson has five or more assists in nine consecutive games.
It was the fifth time in Mosqueda-Lewis' career that she reached double figures in points and rebounds.
UConn's winning streak is tied for fifth all-time in program history, matching one that ran from Feb. 5, 2000 to Jan. 13, 2001. The Huskies also have the top two winning streaks in NCAA Division I history, winning 90 straight between 2008-11 and 70 in a row from 2001-03.
Stewart needs just 41 more points to to reach 1,000 for her career.
The Huskies played with just seven scholarship players. Guard Brianna Banks missed the game after re-spraining her left ankle in practice on Monday. She missed a game against South Florida a week ago with a similar injury.
Hartley scored in double figures for the eighth straight game. She needs just 14 rebounds and five assists to join Diana Taurasi and Moore as the only players in team history with 1,500 points, 500 rebounds and 500 assists.
No. 4 Louisville 74, UCF 59: Asia Taylor's double-double of 19 points and 12 rebounds led a balanced Louisville scoring effort as the fourth-ranked Cardinals downed Central Florida in an American Athletic Conference game.
Sara Hammond had 14 points, Shoni Schimmel 11 and Emmanuel Henderson 10 for the Cardinals (23-1 overall, 11-0 American Athletic Conference), who face top-ranked UConn on Sunday.
The Cardinals finally pulled away when Schimmel and Hammond combined for 10 points on a 15-3 run that gave Louisville a 58-38 lead on Taylor's 3-pointer with 12 minutes to play.
UCF (9-13, 2-9) got as close as 63-53 on a Andrea Hines three-pointer with 5:31 left, but could come no closer.
Henderson, a freshman, did all her scoring in eight minutes in the first half as the Cardinals took a 44-33 halftime lead.
Sara Djassi led the Knights with 12 points.