Seattle (4-2) at San Francisco (4-2)
When: 7:20 p.m. today.
TV: NFL Network.
Line: 49ers -7 (38).
The skinny: If you go by last week alone, these teams are going in opposite directions. The Seahawks rallied from being down two touchdowns to beat the Patriots. The Niners, though, were routed by the Giants at home. You best believe San Fran's defense will be looking to make amends for giving up 26 at home, and Alex Smith will want to atone for his three picks. The NFC West lead is on the line, but the Seahawks are not the Giants.
MattE's pick: 49ers 27, Seahawks 13.