Mathew Sims hit a 36-yard field goal with four seconds left and Northern Illinois rallied to beat Iowa 30-27 on Saturday in the season opener for both teams.
Mount Carmel graduate Jordan Lynch threw for 275 yards and three touchdowns for the Huskies, who scored 10 points in the final 5:05 to record their first win over the Hawkeyes.
Northern Illinois cornerback Jimmie Ward intercepted Iowa's Jake Rudock with 1:17 left. He brought it to the Hawkeyes 30-yard line, setting up the game-winning kick from Sims.
Rudock threw for 256 yards, a touchdown and two picks in his debut for Iowa, which lost its seventh straight game dating back to last season.
The Hawkeyes also lost their first opener since 2000.
No. 1 Alabama 35, Virginia Tech 10: Christion Jones became the first Alabama player since at least the 1940s to have two returns for touchdowns, Vinnie Sunseri brought back an interception for another TD, and the Crimson Tide overcame a sluggish offensive performance to beat Virginia Tech.
No. 2 Ohio St. 40, Buffalo 20: Braxton Miller threw two touchdown passes before fighting leg cramps and Jordan Hall ran for two more scores to lead Ohio State to a victory over Buffalo in the season opener for both teams.
No. 3 Oregon 66, Nicholls 3: Marcus Mariota threw a touchdown pass and ran for two additional scores and the Oregon Ducks made easy work of lower-tier Nicholls.
No. 7 Texas A&M 52, Rice 31: After serving his first-half suspension, Heisman Trophy winner Johnny Manziel threw three TD passes and scrambled for 19 yards — ran his mouth a bit, too — as Texas A&M posted a lopsided win over Rice. Manziel was sitting out because of what the school said was an "inadvertent" violation of NCAA rules involving signing autographs.
No. 10 Florida 24, Toledo 6: Mack Brown had a career day, Jeff Driskel was efficient and Florida opened the season with a victory over Toledo.
No. 13 Oklahoma St. 21, Mississippi St. 3: J.W. Walsh threw for 135 yards and ran for another 125 and a touchdown to lead the Oklahoma State Cowboys to a win over the Mississippi State in the Texas Kickoff.
No. 16 Oklahoma 34, Louisiana-Monroe 0: Trevor Knight rushed for 103 yards on 13 carries and threw three touchdown passes - two to Jalen Saunders - in his first start and Oklahoma beat Louisiana-Monroe.
No. 17 Michigan 59, Central Michigan 9: Devin Gardner ran for two touchdowns and threw for another in the first half as Michigan went on to beat Central Michigan. It was the highest-scoring opener for the Wolverines (1-0) since 1905, when they beat Ohio Wesleyan 65-0. They will face a tougher test against No. 14 Notre Dame next week at home in a prime-time game.
No. 18 Nebraska 37, Wyoming 34: Ameer Abdullah and Imani Cross each ran for more than 100 yards; Taylor Martinez passed for three touchdowns, and Nebraska survived two late turnovers to defeat Wyoming.
No. 23 Wisconsin 45, Massachusetts 0: Melvin Gordon ran for 144 yards, James White added 143 and Wisconsin's revamped defense pitched a shutout of Massachusetts in coach Gary Andersen's debut.
Eastern Washington 49, No. 25 Oregon St. 46: Vernon Adams passed for 411 yards and ran for 107 and the go-ahead score with 18 seconds left as Eastern Washington upset Oregon State to become the third FCS team to beat a ranked FBS team.
Penn State 23, Syracuse 17: Christian Hackenberg threw two touchdown passes in his first college game and the freshman led Penn State to victory against Syracuse.
Valparaiso graduate Sam Ficken kicked three field goals, including a career-best 46-yarder early in the fourth quarter that made it 16-10.
Cincinnati 42, Purdue 7: Munchie Legaux regained his job as the starting quarterback and had a solid showing, throwing for a touchdown and running for another in Cincinnati's victory over Purdue — the Boilermakers' worst opening loss in 17 years.
South Dakota State 55, Butler 14: Austin Sumner threw three touchdown passes, and South Dakota State totaled more than 500 yards of offense in a win against Butler.
Butler's Matt Lancaster passed for 140 yards and threw three interceptions. He was also the Bulldogs' leading rusher, with 6 carries for 63 yards.